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Sabre Wulf
Serie SaGa
Serie Sakura Wars
Sam and Max
Samba De Amigo
Sanxion
SARGON (ajedrez)
Scram
Second Front
Secret of Mana
Secret Weapons of the Luftwaffe
Serie Sega Rally
Serie Seiken Densetsu
Sensible Soccer
Sentimental Graffiti
Serie Serious Sam
Serpent Isle
Seven Cities of Gold
Seventh Guest
Shadow of the Beast
Shadowgate
Shadowman
Shadowrun MUSH
Shanghai Solitaire ("Mahjong")
Shattered Galaxy
Shenmue (2000)
Shogo
Shogun: Total War
Serie Silent Hill
Silent Hunter
Silent Service
Sim Park
SimAnt
Sim Brick
Serie SimCity (1987)
SimCopter
SimEarth (Maxis, 1990)
SimFarm
SimLife
Simon the Sorcerer
The Sims series
The Simpsons Road Rage
The Simpsons Hit 'n Run
Sin
Sinistar
Serie Skies of Arcadia
Smash TV
Snake
Snood
Sokoban
Solar Striker
Soldier of Fortune
Solitaire's Journey
Serie Sonic the Hedgehog
Sonic Adventure
Sonic Adventure 2
Serie Soul Calibur
Soul Edge
Space Ace
Space Channel 5
Space Invaders
Serie Space Quest
Space Simulator
Spacewar (1962)
Spaceward, Ho!
Spasim (PLATO, 1974)
Spellbreaker
Serie Spelljammer
Spheres of Chaos
Spice World
Serie Spyro
Serie Star Control (Accolade, 1990, 1992, 1996)
Serie StarCraft (Blizzard, 1997)
Starflight (1986)
Star Fox Adventures
Serie Star Fox
Serie Starglider
Star Legions
Stars!
Starship Titanic
Starsiege: Tribes
Startopia
Start-Up
Star Trek
Star Trek: Armada
Star Trek: Armada II
Star Wars DroidWorks
Star Wars Galactic Battlegrounds (2001)
Star Wars Galaxies (2003)
Star Wars: Knights of the Old Republic
Serie Star Wars: Rogue Squadron (LucasArts, 1998, 2001, 2003)
Serie Steel Beasts (eSim Games, 2000, 2004)
Steel Panthers
Strategic Conquest
Serie Street Fighter
Street Racer (Atari, 1977)
Strike Fleet
Stunt Island (Disney Interactive, 1992)
Suikoden series
Super Breakout (Atari)
Serie Super Mario Brothers
Super Mario Brothers 2
Super Mario Brothers 3 (1990)
Super Mario All-Stars (1993)
Super Mario 64 (1996)
Super Mario RPG
Super Mario Sunshine
Paper Mario
Serie Super Smash Bros. (1999)
Super Smash Bros. Melee (2001)
Super Zaxxon
Sword of Aragon
Sword of Sodan
Serie Syndicate (Bullfrog)
Serie System Shock (1994, 1999)

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Fuente: Wikipedia